Methylome-Seq is a hybridization based methylation analysis tool for detecting the methylation state of hyper- or hypo-methylated genomic regions. Bisulfite sequencing is the gold standard for DNA methylation state analysis and also the first assay system that allows comprehensive study of genome-wide DNA methylation profile. Methylome-Seq leverages the advantages of target region capture array and bisulfite sequencing, and focuses on the most relevant genomic regions in epigenomic research areas including regions associated with cancer, genomic imprinting disorder, behavioural and neurological disorder, etc., gives excellent genome coverage for epigenomic research. Compared to WGBS, Methylome-Seq delivers higher throughput with lower cost. Methylome-Seq is also able to detect the methylation state of regions that cannot be isolated by RRBS or immunoprecipitation approaches.
Sample Requirement
Sample Type: Genomic DNA
Amount: DNA >= 5 ug; concentration >= 100 ng/ul
Purity: OD260/280 = 1.7~2.0
Sample without severe degradation
Service Workflow
1. Array capture of targeted regions
Deliverables
1. Primer sequences
2. Base calling result
3. Project closure report
